Loxoprofen-d3
Loxoprofen-d3 is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen can reduce atherosclerosis and shows antitumor activity[1][2][3][4][5].
Product Specifications
UNSPSC
12352005
Target
COX; Isotope-Labeled Compounds
Type
Reference compound
Related Pathways
Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology
Smiles
O=C1CCCC1CC2=CC=C(C=C2)C(C(O)=O)C([2H])([2H])[2H]
Molecular Formula
C15H15D3O3
Molecular Weight
249.32
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Hamaguchi M, et al. Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation. J Clin Biochem Nutr. 2010 Sep;47 (2) :138-47.|[3]Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14 (5) :1201-1203.|[4]Kanda A, et al. Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor. Acta Oncol. 2003;42 (1) :62-70.|[5]Paudel S, et al. Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators. Pharmaceutics. 2019;11 (9) :479. Published 2019 Sep 16.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940034-100 1x 100 µL
Cytokeratin 8/18 (C-51), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740158-100 1x 100 µL
Cytokeratin 17 (E3), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940253-100 1x 100 µL
Cytokeratin, LMW (AE-1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC681969-500 1x 500 µL
Thyroglobulin (Thyroidal Cell Marker) (r6E1), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC882056-500 1x 500 µL
CD7 (T-Cell Leukemia Marker) (CD7/3737), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details