Human/Mouse/Rat GDF11 Protein, His tag
GDF11
Product Specifications
Background
Vascular GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves the arrest of the progenitor cell cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggest that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant Human/Murine/Rat GDF-11 is highly homologous to myostatin/GDF-8, sharing 90% amino acid sequence identity
Product Name Alternative
Bone morphogenetic protein 11, Growth/Differentiation Factor-11, GDF-11, BMP11
Gene ID
10220
Accession Number
O95390
Tag
GDF11
Type
Cytokines and proteins
Applications
His tag
Purity
> 95 % as determined by SDS-PAGE
Activity
Testing in progress
Molecular Formula
12.6 kDa
Molecular Weight
12.6 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin : < 0.1 EU per μg of the protein as determined by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage
Protein Length
The recombinant Human/Mouse/Rat GDF-11 consists of 109 amino acids and predicts a molecular mass of 12.6 kDa.
Formulation
Lyophilized from sterile 20mM Tris, 50mM NaCl, pH 9.0.
Applications Notes
Human/Mouse/Rat
Other Product Names
Bone morphogenetic protein 11, Growth/Differentiation Factor-11, GDF-11, BMP11, GDF11, BMP-11, //11, His- (GDF11), Human/Mouse/Rat GDF11 Protein, His tag
Recommended Usage
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions
Preparation
E.coli
Accession Number URL
https://www.uniprot.org/uniprotkb/O95390/entry#sequences
AA Sequence
Amino acid sequence derived from Human/Murine/Rat GDF-11 (Asn299-Ser407) (O95390) was expressed with 6xHis Tag.
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