Isatin-β-thiosemicarbazone

Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc) . Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits

Product Specifications

CAS Number

[27830-79-1]

Product Name Alternative

IBT

UNSPSC

12352005

Hazard Statement

H301

Target

HSV; Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/isatin-β-thiosemicarbazone.html

Concentration

10mM

Purity

99.58

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C=CC=C2)/C1=N/NC(N)=S

Molecular Formula

C9H8N4OS

Molecular Weight

220.26

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Meis RJ, et al. Genetic and molecular biological characterization of a vaccinia virus gene which renders the virus dependent on isatin-beta-thiosemicarbazone (IBT) . Virology. 1991 Jun;182 (2) :442-54.|[2]Katz E, et al. Synthesis of vaccinia virus polypeptides in the presence of isatin-beta-thiosemicarbazone. Antimicrob Agents Chemother. 1973 Jul;4 (1) :44-8. |[3]Iou-Jiun Kang, et al. Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors. Bioorg Med Chem Lett. 2011 Apr 1;21 (7) :1948-52.|[4]William D Arndt, et al. Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus. Virology. 2016 Oct;497:125-135.