Glucocorticoid receptor agonist-1 Ala-Ala-Mal

Glucocorticoid receptor agonist-1 Ala-Ala-Mal (compound 88) is a glucocorticosteroid, and an agonist of glucocorticoid receptor. Glucocorticoid receptor agonist-1 Ala-Ala-Mal can be conjugated with Adalimumab (HY-P9908) to prepare an ADC[1].

Product Specifications

CAS Number

[2166376-51-6]

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC; Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/glucocorticoid-receptor-agonist-1-ala-ala-mal.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@]([C@@]1([H])C[C@@]2([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(C=C4)C)([H])[C@H]5O)(O[C@@](C(C=C6)=CC=C6CC7=CC(NC([C@H](C)NC([C@H](C)NC(CCN(C8=O)C(C=C8)=O)=O)=O)=O)=CC=C7)([H])O1)[C@]2(C5)C)CO

Molecular Formula

C48H54N4O11

Molecular Weight

862.96

References & Citations

[1]McPherson, et al. Preparation of glucocorticoid receptor agonist and immunoconjugates thereof: World Intellectual Property Organization, WO2017210471[P]. 2017-12-07.