Osavampator

Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM) . Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders[1][2].

Product Specifications

CAS Number

[1358751-06-0]

Product Name Alternative

TAK-653; NBI-1065845

UNSPSC

12352005

Target

IGluR; Lipoxygenase

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/osavampator.html

Purity

99.74

Solubility

DMSO : ≥ 12.5 mg/mL

Smiles

O=S1(N=C2C(C3=CC=C(C=C3)OC4CCCCC4)=NC(C)=CN2CC1)=O

Molecular Formula

C19H23N3O3S

Molecular Weight

373.47

References & Citations

[1]Hara H, et al. TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats. Pharmacol Biochem Behav. 2021 Dec;211:173289. |[2]Hara H, et al. TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats [J]. Pharmacology Biochemistry and Behavior, 2021, 211: 173289.|[3]Suzuki A, et al. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement [J]. Scientific Reports, 2021, 11 (1) : 14532.