GDNF Antibody

Detects ~24 kDa. In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change.

[glial cell line-derived neurotrophic factor isoform 5; Glial cell line-derived neurotrophic factor; glial cell line-derived neurotrophic factor; glial cell derived neurotrophic factor; Astrocyte-derived trophic factor]