(E/Z) -HA155

(E/Z) -HA155 is a potent autotaxin (ATX) type I inhibitor. (E/Z) -HA155 can be used for researching cancer, fibrotic diseases, inflammation, pain and angiogenesis[1].

Product Specifications

CAS Number

[1229652-22-5]

Product Name Alternative

KPT-8602

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e-z-ha155.html

Concentration

10mM

Purity

99.58

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OB(O)C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=C(C3=O)\SC(N3CC4=CC=C(C=C4)F)=O

Molecular Formula

C24H19BFNO5S

Molecular Weight

463.29

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Joncour A, et al. Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors [published correction appears in J Med Chem. 2018 May 10;61 (9) :4270]. J Med Chem. 2017;60 (17) :7371-7392.