BWA-522 intermediate-2
BWA-522 intermediate-2 is a BWA-522 intermediate. BWA-522 is an orally available small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7[1].
Product Specifications
UNSPSC
12352005
Target
Drug Intermediate
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bwa-522-intermediate-2.html
Purity
99.87
Solubility
10 mM in DMSO
Smiles
CC(C)(C1=CC=C(OC[C@@H](O)CCl)C=C1)C2=CC=C(OCC3CCN(C(OC(C)(C)C)=O)CC3)C=C2
Molecular Formula
C29H40ClNO5
Molecular Weight
518.08
References & Citations
[1]Zhang B, et al. Discovery of BWA-522, a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate Cancer. J Med Chem. 2023 Aug 24;66 (16) :11158-11186.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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