H2S probe 1
H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC50=77.9 nM) and has a high affinity for human telomeric G-quadruplex (G4) (Kd=1.72 μM) . H2S probe 1 can be used in cancer research[1].
Product Specifications
UNSPSC
12171500
Target
G-quadruplex
Type
Dye Reagents
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/h2s-probe-1.html
Smiles
O=C(N(CCCN1CCOCC1)C2=O)C3=CC=C4C5=C(C(N(CCCN6CCOCC6)C4=O)=O)C=C(NCCN7CCN(C8=CC=C([N+]([O-])=O)C9=NON=C98)CC7)C2=C53
Molecular Formula
C40H46N10O9
Molecular Weight
810.85
References & Citations
[1]Xinhang Zhang, et al. "Design and synthesis of dual functional NBD-fluorophore-incorporated naphthalene diimide derivatives as G-quadruplex ligands." Bioorganic & Medicinal Chemistry Letters 111 (2024) : 129903.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Frequently Asked Questions
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