Tasipimidine (sulfate)

Tasipimidine sulfate is an orally active and selective α2A-adrenoceptor agonist with a pEC50 of 7.57 for human α2A-adrenoceptors and an EC50 of 5.7 nM for rat α2-adrenoceptor. Tasipimidine sulfate can be utilized in research related to situational anxiety and fear[1][2].

Product Specifications

CAS Number

[1465908-73-9]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tasipimidine-sulfate.html

Purity

99.32

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=S(O)(O)=O.COC1=CC=CC2=C1CCOC2C3=NCCN3

Molecular Formula

C13H18N2O6S

Molecular Weight

330.36

References & Citations

[1]Lehtimäki J, et al. Tasipimidine-the pharmacological profile of a novel orally active selective α2A-adrenoceptor agonist. Eur J Pharmacol. 2022 May 15;923:174949.|[2]Korpivaara M, et al. Tasipimidine, a novel orally administered alpha-2 adrenoceptor agonist, alleviates canine acute anxiety associated with owner departure—A pilot study. Journal of Veterinary Behavior, 2022, 58: 54-61.