ETB
Product Specifications
CAS Number
634589-47-2
UNSPSC Description
ETB is a potent Hsp60 chaperone activity inhibitor. ETB blockes the chaperone activities of the wild-type protein and of the C237A and C447A mutant proteins. ETB binds to Hsp60 Cys442 and shows the resistance of the C442A mutant to ETB inhibition[1].
Target Antigen
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/etb.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C)OC(C(/C=C(C)/C=C/CC/C=C(C)/C([C@@]12[C@@](C(O)(NC2=O)C)([H])O1)=O)=C/C)=O
Molecular Weight
431.52
References & Citations
[1]Nagumo Y, et al. Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity. Biochem J. 2005 May 1;387(Pt 3):835-40.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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