Atosiban

Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research[1].

Product Specifications

CAS Number

[90779-69-4]

Product Name Alternative

RW22164; RWJ22164

UNSPSC

12352209

Hazard Statement

H360

Target

Oxytocin Receptor; Vasopressin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Endocrinology; Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Atosiban.html

Purity

99.09

Solubility

DMSO : ≥ 16.67 mg/mL|H2O : 16.67 mg/mL (ultrasonic)

Smiles

O=C([C@H](CSSCCC(N[C@@H](C1=O)CC2=CC=C(OCC)C=C2)=O)NC([C@@H](NC(C(NC([C@](N1)([H])[C@@H](C)CC)=O)[C@H](O)C)=O)CC(N)=O)=O)N(CCC3)[C@@H]3C(N[C@@H](CCCN)C(NCC(N)=O)=O)=O

Molecular Formula

C43H67N11O12S2

Molecular Weight

994.19

Precautions

H360

References & Citations

[1]Sanu O, et al. Critical appraisal and clinical utility of atosiban in the management of preterm labor. Ther Clin Risk Manag. 2010 Apr 26;6:191-9.|[2]Philip J Ryan, et al. Oxytocin-receptor-expressing Neurons in the Parabrachial Nucleus Regulate Fluid Intake. Nat Neurosci. 2017 Dec;20 (12) :1722-1733.