Zingiberen newsaponin

Zingiberen Newsaponin (Zingiberensis newsaponin) is an orally active type of steroid saponin compound. Zingiberen Newsaponin exerts anti-hepatocellular carcinoma (HCC) effects by inhibiting autophagy and the AKR1C1/JAK2/STAT3 pathway. Zingiberen Newsaponin activates oxidative stress (upregulates ROS and MDA) and mitochondrial pathways, promoting cancer cell apoptosis. Zingiberen Newsaponin alleviates cerebral ischemia-reperfusion (I/R) injury by decreasing the concentration of pro-inflammatory cytokines and inhibits NF-κB. Zingiberen Newsaponin can enhance the activity of SOD, eliminate free radicals and protect nerve cells. Zingiberen Newsaponin induces platelet aggregation[1][2][3].

Product Specifications

CAS Number

[91653-50-8]

Product Name Alternative

Zingiberensis newsaponin

UNSPSC

12352005

Target

Aldose Reductase; Apoptosis; Autophagy; JAK; NF-κB; Reactive Oxygen Species (ROS) ; SOD; STAT

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/zingiberen-newsaponin.html

Purity

99.68

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])C[C@@]1([H])[C@@](CC=C5[C@@]6(CC[C@H](O[C@@](O[C@H](CO)[C@@H](O[C@@](O[C@H](CO)[C@@H](O)[C@@H]7O[C@]([C@@H]([C@@H](O)[C@@H]8O)O)([H])O[C@@H]8CO)([H])[C@@H]7O)[C@@H]9O)([H])[C@@H]9O[C@@](O[C@@H](C)[C@H](O)[C@H]%10O)([H])[C@@H]%10O)C5)C)([H])[C@]6([H])CC2

Molecular Formula

C51H82O22

Molecular Weight

1047.18

References & Citations

[1]Wang JJ, et al. Study on steroidal saponins from Dioscorea zingiberensis and their platelet aggregation activities. Zhongguo Zhong Yao Za Zhi. 2014 Oct;39 (19) :3782-7.|[2]He K, et al. Zingiberensis Newsaponin Inhibits the Malignant Progression of Hepatocellular Carcinoma via Suppressing Autophagy Moderated by the AKR1C1-Mediated JAK2/STAT3 Pathway. Evid Based Complement Alternat Med. 2021 Dec 13;2021:4055209.|[3]Xue Z, et al. New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect. Food Funct. 2021 Sep 20;12 (18) :8314-8325.