20-Deoxyingenol
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA) [1][2].
Product Specifications
CAS Number
54706-99-9
UNSPSC
12352211
Target
Autophagy
Type
Natural Products
Related Pathways
Autophagy
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/20-Deoxyingenol.html
Purity
98.77
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1[C@@]2(C=C(C)[C@@H]3O)[C@]3(O)[C@H](O)C(C)=C[C@@]1([H])[C@@]4([H])[C@@](C4(C)C)([H])C[C@H]2C
Molecular Formula
C20H28O4
Molecular Weight
332.43
References & Citations
[1]Uemura D, et, al. Isolation and structures of 20-deoxyingenol new diterpene, derivatives and ingenol derivative obtained from “kansui”. Tetrahedron Letters. 1974; 15 (29) : 2527-2528.|[2]Gu M, et, al. 20-Deoxyingenol alleviates osteoarthritis by activating TFEB in chondrocytes. Pharmacol Res. 2021 Jan 15;165:105361.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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