XL-126

XL-126 (Compound 33) is a potent BD1-selective BET inhibitor, with a Kd of 8.9 nM. XL-126 leads to both the preservation of platelets and potent anti-inflammatory efficacy by BD1 selectivity[1].

Product Specifications

CAS Number

[3033576-12-1]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/xl-126.html

Solubility

10 mM in DMSO

Smiles

O=C1C(NC2CCNCC2)=CC(C3=CC(NS(=O)(CC)=O)=C(C4=C3)C=CN4C(C)(C5=NC=CC=C5)C6=CC=CC=N6)=CN1C

Molecular Formula

C33H37N7O3S

Molecular Weight

611.76

References & Citations

[1]Li Y, et al. Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET) -First Bromodomain (BD1) Inhibitors. J Med Chem. 2024 Jan 31.