Amentoflavone

Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA (A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4].

Product Specifications

CAS Number

[1617-53-4]

Product Name Alternative

Didemethyl-ginkgetin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bacterial; Fungal; GABA Receptor; Reactive Oxygen Species (ROS) ; RSV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Amentoflavone.html

Concentration

10mM

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(O)=CC(O)=C13

Molecular Formula

C30H18O10

Molecular Weight

538.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang Z, et al. Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects. Neural Regen Res. 2015 Jul;10 (7) :1125-33. |[2]Woo ER, et al. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages. Pharmacol Res. 2005 Jun;51 (6) :539-46.|[3]Woo ER, et al. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages. Pharmacol Res. 2005 Jun;51 (6) :539-46.|[4]Yen TH, et al. Amentoflavone Induces Apoptosis and Inhibits NF-ĸB-modulated Anti-apoptotic Signaling in Glioblastoma Cells. In Vivo. 2018 Mar-Apr;32 (2) :279-285.|[5]Hwang JH, et al. Antibacterial effect of amentoflavone and its synergistic effect with antibiotics. J Microbiol Biotechnol. 2013;23 (7) :953-8.|[6]Hanrahan JR, et al. Semisynthetic preparation of amentoflavone: A negative modulator at GABA (A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13 (14) :2281-4.