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Cabazitaxel

Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

Product Specifications

CAS Number

[183133-96-2]

Product Name Alternative

XRP6258; RPR-116258A; taxoid XRP6258

UNSPSC

12352005

Hazard Statement

H302, H315, H341, H361, H373

Target

Autophagy; Microtubule/Tubulin

Type

Natural Products

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Cabazitaxel.html

Purity

99.98

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC1=C([C@@H](OC)C([C@@]2(C)[C@@]3([H])[C@](OC(C)=O)(CO4)[C@H]4C[C@@H]2OC)=O)C(C)(C)[C@@]([C@H]3OC(C5=CC=CC=C5)=O)(O)C[C@@H]1OC([C@H](O)[C@H](C6=CC=CC=C6)NC(OC(C)(C)C)=O)=O

Molecular Formula

C45H57NO14

Molecular Weight

835.93

Precautions

H302, H315, H341, H361, H373

References & Citations

[1]Tai X, et al. Cabazitaxel and indocyanine green co-delivery tumor-targeting nanoparticle for improved antitumor efficacy and minimized drug toxicity. J Drug Target. 2016 Sep 9:1-29.|[2]Gdowski AS, et al. Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. Nanomedicine (Lond) . 2017 Sep;12 (17) :2083-2095.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-15459/Cabazitaxel-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-15459/Cabazitaxel-SDS-MedChemExpress.pdf

Scientific Category

Natural Products

Clinical Information

Launched

Available Sizes

Curated Selection

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