BGC-20-1531

Product Specifications

UNSPSC Description

BGC-20-1531 (PGN 1531), a benzenesulfonamide derivative, is a selective EP4 antagonist. BGC-20-1531 binds to PGE2 enhancing the ATPase activity, which are coupled to Gs proteins and thus activate adenylate cyclase generating cAMP and activating PKA. BGC-20-1531 is promising for research of liver disorders[1][2].

Target Antigen

PKA; Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein;Stem Cell/Wnt;TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/bgc-20-1531.html

Smiles

O=C(C1=CC(COC2=CC=C(C3=NC=C(C=C3)OC)C=C2)=C(C)O1)N([Na])S(=O)(C4=C(C)C=CC=C4)=O

Molecular Weight

514.53

References & Citations

[1]Ammazzalorso A, et al. N-acylsulfonamides: Synthetic routes and biological potential in medicinal chemistry. Chem Biol Drug Des. 2017 Dec;90(6):1094-1105.|[2]Hodeify R, et al. PGE2 upregulates the Na+/K+ ATPase in HepG2 cells via EP4 receptors and intracellular calcium. PLoS One. 2021 Jan 14;16(1):e0245400.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-W394717/BGC-20-1531-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-W394717/

Clinical Information

Phase 2

CAS Number

1186532-61-5

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