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Goat anti Mouse Disabled-1 (NT)

Product Specifications

Background

Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled Ð1 acts downstream of reelin in a signalling pathway.

CAS Number

9007-83-4

Synonyms

Disabled homolog 1, DAB1

UniProt

P97318 (Mouse)

Host

Goat

Species Reactivity

Mouse

Isotype

IgG

Conjugation

Unconjugated

Type

Polyclonal Antibody

Source

Goats were immunized with a recombinant protein corresponding to amino acids 1-179 of mouse disabled coupled to a GST fusion protein.

Applications

WB

Field of Research

Signal Transduction

Purification Method

Ammonium Sulfate Precipitation

Assay Principle

Immunoblotting at 1-5 µg/mL, Immunoprecipitation at 5-10µg/mL. Optimal concentration should be evaluated by serial dilutions.

Stability

See expiration date on vial

Concentration

See vial for Concentration

Form

Provided as 0,2 mL sterile filtered solution in phosphate buffered saline with 0,08% sodium azide

Precautions

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

References & Citations

1. Howell B.W. et.al (1997). EMBO Journal 1,121-132_x000D_ 2. Homayouni,R. et.al (1999) J. Neuroscience 19(17), 7505-7515

Shipping Conditions

Ambient Temperature, freeze upon arrival

Storage Conditions

Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

Functional Analysis

WB

Frequently Asked Questions

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