3-Methyl-GABA

3-Methyl-GABA is a potent GABA aminotransferase activator. 3-Methyl-GABA can fit the binding pocket of GABAA receptor (GABAaR) . 3-Methyl-GABA can activate L-glutamic acid decarboxylase (GAD) . 3-Methyl-GABA has anticonvulsant activity[1][2].

Product Specifications

CAS Number

[1216629-00-3]

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3-methyl-gaba.html

Purity

99.86

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=S(C1=C2C=CC=C(S(=O)(O)=O)C2=CC=C1)(O)=O.O=C(O)CC(C)CN.O=C(O)CC(C)CN

Molecular Formula

C20H30N2O10S2

Molecular Weight

522.59

References & Citations

[1]R B Silverman, et al. 3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase. J Med Chem. 1991 Jul;34 (7) :2295-8.|[2]Z. YANG, et al. MOLECULAR INTERACTIONS OF GABA ANALOGUES AGAINST THE α+β-INTERFACE OF GABAARECEPTOR: DOCKING AND MOLECULAR DYNAMICS STUDIES. Digest Journal of Nanomaterials and Biostructures, Vol. 10, No. 3, July -September 2015.