Buparlisib (Hydrochloride)
Buparlisib Hydrochloride (BKM120 Hydrochloride) is a pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively.
Product Specifications
CAS Number
[1312445-63-8]
Product Name Alternative
BKM120 (Hydrochloride) ; NVP-BKM120 (Hydrochloride)
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NVP-BKM120-Hydrochloride.html
Concentration
10mM
Purity
99.51
Solubility
DMSO : ≥ 50 mg/mL
Smiles
NC(N=C1)=CC(C(F)(F)F)=C1C2=NC(N3CCOCC3)=NC(N4CCOCC4)=C2.[H]Cl
Molecular Formula
C18H22ClF3N6O2
Molecular Weight
446.85
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Burger MT, et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Med Chem Lett. 2011 Aug 26;2 (10) :774-9.|[2]Zheng Y, et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl) . 2012 Jun;90 (6) :695-706.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34
Citation 01
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