D-erythro-Sphingosine

D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC) . D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

Product Specifications

CAS Number

[123-78-4]

Product Name Alternative

Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Phosphatase; PKC

Type

Natural Products

Related Pathways

Epigenetics; Metabolic Enzyme/Protease; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/D-erythro-Sphingosine.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO

Molecular Formula

C18H37NO2

Molecular Weight

299.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Pushkareva MYu, et al. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid basesand inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15;294 (Pt 3) :699-703.|[2]Khan WA, et al. Protein kinase C and platelet inhibition by D-erythro-Sphingosine: comparison with N, N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30;172 (2) :683-91.|[3]Pham VT, et al. A concise synthesis of a promising protein kinase C inhibitor: D-erythro-Sphingosine. Arch Pharm Res. 2007 Jan;30 (1) :22-7.|[4]Cheng P, et al. Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS. J Neurol Sci. 2015 Dec 15;359 (1-2) :48-56.