Tryptanthrin

Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α[1][2].

Product Specifications

CAS Number

[13220-57-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX; Interleukin Related; Leukotriene Receptor; NF-κB; NO Synthase; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tryptanthrin.html

Purity

99.89

Solubility

DMSO : 7.14 mg/mL (ultrasonic)

Smiles

O=C1C2=CC=CC=C2N3C(C4=CC=CC=C4N=C13)=O

Molecular Formula

C15H8N2O2

Molecular Weight

248.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Zeng Q, et, al. Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment. Acta Pharm. 2021 Jun 1;71 (2) :245-266.|[2]Pergola C, et, al. On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo. Br J Pharmacol. 2012 Feb;165 (3) :765-76.