Tryptanthrin
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α[1][2].
Product Specifications
CAS Number
13220-57-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX; Interleukin Related; Leukotriene Receptor; NF-κB; NO Synthase; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tryptanthrin.html
Purity
99.89
Solubility
DMSO : 7.14 mg/mL (ultrasonic)
Smiles
O=C1C2=CC=CC=C2N3C(C4=CC=CC=C4N=C13)=O
Molecular Formula
C15H8N2O2
Molecular Weight
248.24
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IL-10; IL-12; IL-2; IL-6; nNOS; TNFRSF5/CD40
Available Sizes
Frequently Asked Questions
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