Androsin

Androsin is an active compound isolated from Picrorhiza Kurroa Royle ex Benth. Androsin activates AMPKα/PI3K/Beclin1/LC3 signaling pathway, inhibits SREBP1c/FASN signaling pathway. Androsin can be used in research of asthma and non-alcoholic fatty liver disease (NAFLD) . Androsin is orally active[1][2].

Product Specifications

CAS Number

[531-28-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

AMPK; Autophagy; PI3K

Type

Natural Products

Related Pathways

Autophagy; Epigenetics; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/androsin.html

Purity

99.94

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(C1=CC=C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)C(OC)=C1)=O

Molecular Formula

C15H20O8

Molecular Weight

328.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Dorsch W, et al. Antiasthmatic effects of Picrorhiza kurroa: androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigs. Int Arch Allergy Appl Immunol. 1991;95 (2-3) :128-33.|[2]Singh A, et al., Androsin alleviates non-alcoholic fatty liver disease by activating autophagy and attenuating de novo lipogenesis. Phytomedicine. 2024 Jul;129:155702.