Tamapin

Tamapin is a venom peptide, targeting to small conductance Ca (2+) -activated K (+) (SK) channels. Tamapin is a selctive blocker of SK2 (Potassium Channel) . Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus) [1].

Product Specifications

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tamapin.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CCC(O)=O)C(N[C@H]2CCC(O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@@H](C(N[C@H]4CCCCN)=O)NC2=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](C(C)C)C(N5[C@@H](CCC5)C(N[C@@H](CC6=CC=C(C=C6)O)C(N)=O)=O)=O)=O)NC4=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@H]3CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Molecular Formula

C146H238N44O41S6

Molecular Weight

3458.11

References & Citations

[1]Pedarzani P, et al. Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons. J Biol Chem. 2002 Nov 29;277 (48) :46101-9.