Stachydrine
Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.
Product Specifications
CAS Number
471-87-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; NF-κB
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Stachydrine.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
C[N+]1(C)[C@H](C([O-])=O)CCC1
Molecular Formula
C7H13NO2
Molecular Weight
143.18
Precautions
H302, H315, H319, H335
References & Citations
[1]Guo W, et al. Effect of Leonurus stachydrine on myocardial cell hypertrophy. Zhong Yao Cai. 2012 Jun;35 (6) :940-3.|[2]Yin J, et al. Stachydrine, a major constituent of the Chinese herb leonurus heterophyllus sweet, ameliorates human umbilical vein endothelial cells injury induced by anoxia-reoxygenation. Am J Chin Med. 2010;38 (1) :157-71.|[3]Rathee P, et al. In vitro anticancer activity of stachydrine isolated from Capparis decidua on prostate cancer cell lines. Nat Prod Res. 2012;26 (18) :1737-40.|[4]Zhang C, et al. Effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients. BMC Complement Altern Med. 2014 Dec 8;14:474.|[5]Zhang C, et al. Effect of stachydrine on endoplasmic reticulum stress-induced apoptosis in rat kidney after unilateral ureteral obstruction. J Asian Nat Prod Res. 2013;15 (4) :373-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
RelA/p65
Citation 01
Exp Eye Res. 2025 Aug 14:260:110568.|Food Funct. 2020 Dec 1;11 (12) :10864-10875.|J Agric Food Chem. 2019 Sep 4;67 (35) :9805-9811.|J Cardiothorac Surg. 2023 Sep 26;18 (1) :265.|J Food Meas Charact. 2024 Jul 12.|Phytomedicine. 2025 Sep:145:156951.|Rev Bras Farmacogn. 2025 Sep 4.|Mol Plant Microbe Interact. 2025 Aug 10.|Toxicol Appl Pharmacol. 2025 May:498:117301.
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