Azaphen (dihydrochloride monohydrate)
Pipofezine (Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. IC50 Value: Target: SSRIs Pipofezine is a tricyclic antidepressant (TCA) approved in Russia for the treatment ofdepression.
Product Specifications
CAS Number
63302-99-8
Product Name Alternative
Azafen dihydrochloride monohydrate; Pipofezin dihydrochloride monohydrate; Pipofezine dihydrochloride monohydrate; Azaphenonxazine dihydrochloride monohydrate
UNSPSC
12352005
Target
Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Azaphen-dihydrochloride-monohydrate.html
Purity
99.94
Solubility
DMSO : 1 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
[H]Cl.[H]Cl.CN1C2=CC=CC=C2OC3=C1C=C(N4CCN(C)CC4)N=N3.O
Molecular Formula
C16H23Cl2N5O2
Molecular Weight
388.29
References & Citations
[1]Shinaev NN, Akzhigitov RG.
 Azaphen: a return to clinical practice.Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105 (10) :55-6.|[2]Ignatowicz L, Ignatowicz R, Wdowiak MW, Jaremko A.
 Azaphen in the treatment of enuresis in children.Psychiatr Pol. 1977 Jan-Feb;11 (1) :29-33.|[3]Liberman SS, Sharova SA.
 A comparison of the effect of the tricyclic antidepressants azaphen and imizin on the gastrointestinal tracts of experimental animals.Farmakol Toksikol. 1975 Jan-Feb;38 (1) :29-32.|[4]Misurec J, Náhunek K, Kamenická V, Chmelar M.
 Proceedings: Influence of azaphen, a new antidepressive drug, on the human EEG.
 Act Nerv Super (Praha) . 1974;16 (4) :245-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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