Azaphen (dihydrochloride monohydrate)

Pipofezine (Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. IC50 Value: Target: SSRIs Pipofezine is a tricyclic antidepressant (TCA) approved in Russia for the treatment ofdepression.

Product Specifications

CAS Number

[63302-99-8]

Product Name Alternative

Azafen dihydrochloride monohydrate; Pipofezin dihydrochloride monohydrate; Pipofezine dihydrochloride monohydrate; Azaphenonxazine dihydrochloride monohydrate

UNSPSC

12352005

Target

Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Azaphen-dihydrochloride-monohydrate.html

Purity

99.94

Solubility

DMSO : 1 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

[H]Cl.[H]Cl.CN1C2=CC=CC=C2OC3=C1C=C(N4CCN(C)CC4)N=N3.O

Molecular Formula

C16H23Cl2N5O2

Molecular Weight

388.29

References & Citations

[1]Shinaev NN, Akzhigitov RG. Azaphen: a return to clinical practice.Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105 (10) :55-6.|[2]Ignatowicz L, Ignatowicz R, Wdowiak MW, Jaremko A. Azaphen in the treatment of enuresis in children.Psychiatr Pol. 1977 Jan-Feb;11 (1) :29-33.|[3]Liberman SS, Sharova SA. A comparison of the effect of the tricyclic antidepressants azaphen and imizin on the gastrointestinal tracts of experimental animals.Farmakol Toksikol. 1975 Jan-Feb;38 (1) :29-32.|[4]Misurec J, Náhunek K, Kamenická V, Chmelar M. Proceedings: Influence of azaphen, a new antidepressive drug, on the human EEG. Act Nerv Super (Praha) . 1974;16 (4) :245-6.