M-PEG-OH (MW 1000)

M-PEG-OH (MW 1000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger cancer-killing activity than free Paclitaxel. And it accumulates preferentially in tumor tissues and has only limited distribution in healthy organs.

Product Specifications

CAS Number

[9004-74-4]

Product Name Alternative

MPEG-Hydroxy (MW 1000) ; Polyethylene glycol monomethyl ether (MW 1000)

UNSPSC

12352200

Hazard Statement

H302-H319-H335-H336-H372

Target

PROTAC Linkers

Type

Biochemical Assay Reagents

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m-peg-oh-mw-1000.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

COCCOCCO.[n]

Molecular Weight

1000 (Average)

Precautions

P260-P261-P264-P270-P271-P280-P304+P340-P305+P351+P338-P330-P403+P233-P405-P501

References & Citations

[1]Lee AL, et al. The use of cholesterol-containing biodegradable block copolymers to exploit hydrophobic interactions for the delivery of anticancer drugs. Biomaterials. 2012 Feb;33 (6) :1921-8.