MNS
MNS (NSC 170724), the beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. MNS inhibits Src, Syk, and FAK with IC50 of 27.3, 2.8, and 97.6 μM, respectively. MNS inhibits NLRP3 inflammasome and β1 integrin. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS is cytotoxic to a variety of cells[1][2][3][4][5][6][7][8][9].
Product Specifications
Product Name Alternative
NSC 170724; 5- (2-Nitrovinyl) benzodioxole
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Integrin; NOD-like Receptor (NLR) ; Src; Syk
Type
Reference compound
Related Pathways
Cytoskeleton; Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MNS.html
Concentration
10mM
Purity
99.60
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=[N+]([O-])/C=C/C1=CC(OCO2)=C2C=C1
Molecular Formula
C9H7NO4
Molecular Weight
193.16
Precautions
H301, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-78263/MNS-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-78263/MNS-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
CAS Number
[1485-00-3]
Available Sizes
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