Anticancer agent 249
Product Specifications
UNSPSC Description
Anticancer agent 249 (Compound 89) is an inhibitor for Hsp90β with IC50 of 16.5 μM in PC3MM2 cell. Anticancer agent 249 inhibits proliferation of cancer cells MCF-7, T47D, MDA-MB-231, MDA-MB-468 and SKBr3 with IC50 of 1.8-5.3 μM. Anticancer agent 249 induces apoptosis in MDA-MB-231. Anticancer agent 249 exhibits antitumor efficacy in mice[1].
Target Antigen
Apoptosis; HSP
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-249.html
Smiles
ClC1=CC=C(NC(C2CCN(CC3=CC=C(OCC4CCNCC4)C=C3)CC2)=O)C=C1Cl
Molecular Weight
476.44
References & Citations
[1]Zajec Ž, et al., New Class of Hsp90 C-Terminal Domain Inhibitors with Anti-tumor Properties against Triple-Negative Breast Cancer. J Med Chem. 2024 Jul 23
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162751/Anticancer-agent-249-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162751/
Clinical Information
No Development Reported
CAS Number
9007-83-4
Curated Selection
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