Anticancer agent 249
Anticancer agent 249 (Compound 89) is an inhibitor for Hsp90β with IC50 of 16.5 μM in PC3MM2 cell. Anticancer agent 249 inhibits proliferation of cancer cells MCF-7, T47D, MDA-MB-231, MDA-MB-468 and SKBr3 with IC50 of 1.8-5.3 μM. Anticancer agent 249 induces apoptosis in MDA-MB-231. Anticancer agent 249 exhibits antitumor efficacy in mice[1].
Product Specifications
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Apoptosis; HSP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-249.html
Smiles
ClC1=CC=C(NC(C2CCN(CC3=CC=C(OCC4CCNCC4)C=C3)CC2)=O)C=C1Cl
Molecular Formula
C25H31Cl2N3O2
Molecular Weight
476.44
References & Citations
[1]Zajec Ž, et al., New Class of Hsp90 C-Terminal Domain Inhibitors with Anti-tumor Properties against Triple-Negative Breast Cancer. J Med Chem. 2024 Jul 23
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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