Hedragonic acid

Hedragonic acid is an oleane-type triterpenoid compound, which can be isolated from the stems and roots of the southern snake vine. Hedragonic acid is a ligand and agonist for FXR. Hedragonic acid protected mice from liver damage caused by acetaminophen overdose and reduced liver inflammation[1].

Product Specifications

CAS Number

[466-02-4]

UNSPSC

12352211

Target

FXR

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hedragonic-acid.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12C([C@@]3([H])[C@](C(O)=O)(CCC(C)(C)C3)CC2)=CC[C@@]4([H])[C@]1(CC[C@]([C@@H]5C)([H])[C@@]4(CCC5=O)C)C

Molecular Formula

C29H44O3

Molecular Weight

440.66

References & Citations

[1]Lu Y, et al. Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity. Mol Pharmacol. 2018 Feb;93 (2) :63-72.