SR3335
SR3335 (ML 176) is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220 nM[1][2].
Product Specifications
CAS Number
293753-05-6
Product Name Alternative
ML 176
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/SR3335.html
Concentration
10mM
Purity
98.49
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(C1=CC=CS1)(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O
Molecular Formula
C13H9F6NO3S2
Molecular Weight
405.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Kumar N, et al. Identification of SR3335 (ML-176) : a synthetic RORα selective inverse agonist. ACS Chem Biol. 2011 Mar 18;6 (3) :218-22.|[2]Rajput C, et al. RORα-dependent type 2 innate lymphoid cells are required and sufficient for mucous metaplasia in immature mice. Am J Physiol Lung Cell Mol Physiol. 2017;312 (6) :L983-L993.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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