SR3335

SR3335 (ML 176) is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220 nM[1][2].

Product Specifications

CAS Number

[293753-05-6]

Product Name Alternative

ML 176

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/SR3335.html

Concentration

10mM

Purity

98.49

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=S(C1=CC=CS1)(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O

Molecular Formula

C13H9F6NO3S2

Molecular Weight

405.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Kumar N, et al. Identification of SR3335 (ML-176) : a synthetic RORα selective inverse agonist. ACS Chem Biol. 2011 Mar 18;6 (3) :218-22.|[2]Rajput C, et al. RORα-dependent type 2 innate lymphoid cells are required and sufficient for mucous metaplasia in immature mice. Am J Physiol Lung Cell Mol Physiol. 2017;312 (6) :L983-L993.