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IL-1R2, Mouse (HEK293, hFc)

IL-1R2 is a competitive endogenous inhibitor of IL-1 signaling. IL-1R2 serves as a decoy receptor and competes with IL-1R1 for IL-1, it can also form a complex with IL-1RAP once it binds IL-1. IL-1R2 is implicated in various IL-1-mediated inflammatory diseases[1]. IL-1R2 Protein, Mouse (HEK293, hFc) is a recombinant mouse IL-1R2 protein with an hFc tag at the C-terminus and is expressed in HEK293 cells. It consists of 355 amino acids (M1-E355) .

Product Specifications

Product Name Alternative

IL-1R2 Protein, Mouse (HEK293, hFc), Mouse, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/il-1r2-protein-mouse-hek293-hfc.html

Molecular Formula

16178 (Gene_ID) P27931 (F14-E355) (Accession)

Molecular Weight

Approximately 91 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

References & Citations

[1]PetersVA, etal.IL-1receptor2 (IL-1R2) anditsroleinimmuneregulation.BrainBehavImmun.2013Aug;32:1-8.|[2]Molgora M, et al. Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8. Immunol Rev. 2018 Jan;281 (1) :233-247.|[3]Lin J, et al. Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis. Cell Death Dis. 2022 Jan 27;13 (1) :90.|[4]Simeoni E, et al. Gene transfer of a soluble IL-1 type 2 receptor-Ig fusion protein improves cardiac allograft survival in rats. Eur J Cardiothorac Surg. 2007 Feb;31 (2) :222-8.

Shipping Conditions

Dry ice.

Scientific Category

Recombinant Proteins

Frequently Asked Questions

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