Thiethylperazine (dimaleate)
Thiethylperazine dimaleate, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine dimaleate is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine dimaleate has anti-emetic, antipsychotic and antimicrobial effects[1][2][3].
Product Specifications
CAS Number
1179-69-7
UNSPSC
12352005
Hazard Statement
H302, H400, H410
Target
Amyloid-β; Bacterial; Dopamine Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/thiethylperazine-dimaleate.html
Purity
99.99
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(SCC)C=C24)CC1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O
Molecular Formula
C30H37N3O8S2
Molecular Weight
631.76
Precautions
H302, H400, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D2 Receptor; H1 Receptor
Citation 01
J Adv Res. 2024 Oct 21:S2090-1232 (24) 00472-7.|ACS Environ Au. 2025 Aug 8.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.
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