Glucosamine (sulfate)

Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

Product Specifications

CAS Number

[29031-19-4]

Product Name Alternative

D-Glucosamine (sulfate)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/glucosamine-sulfate.html

Purity

98.0

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=C[C@H](N)[C@H]([C@@H]([C@@H](CO)O)O)O.O=S(O)(O)=O

Molecular Formula

C6H15NO9S

Molecular Weight

277.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45 (4 Suppl) :S12-7.|[2]Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38 (1) :212-9.|[3]Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44 (5) :1699-706.|[4]Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl) . 2013 Nov;91 (11) :1273-84.