Mal-PEG8-Val-Ala-PABC
Mal-PEG8-Val-Ala-PABC is a cleavable Tesirine linker used in the synthesis of Tesirine, a agent-linker conjugate for ADC[1].
Product Specifications
Product Name Alternative
MP-PEG8-Val-Ala-PABC; MP-PEG8-VA-PABC
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mal-peg8-val-ala-pabc.html
Purity
99.06
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)C(C)C)=O)C)NC2=CC=C(C=C2)CO
Molecular Formula
C41H65N5O15
Molecular Weight
867.98
References & Citations
[1]Congreve, S., et al. Antibody drug conjugates (ADC) : Current status and mapping of ADC:s in clinical programs.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
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SUMO1 (Small Ubiquitin-related Modifier 1, SUMO-1, GAP-modifying Protein 1, GMP1, Sentrin, SMT3 Homolog 3, SMT3H3, Ubiquitin-homology Domain Protein PIC1, PIC1, Ubiquitin-like Protein SMT3C, Smt3C, Ubiquitin-like Protein UBL1, UBL1) (AP)