ML198
ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1]. ML198 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
1380716-06-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ml198.html
Purity
98.0
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C)
Smiles
O=C(NC1=CC=C(C=C1)C#C)C2=C3N=C(C=C(N3N=C2)C)C
Molecular Formula
C17H14N4O
Molecular Weight
290.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Steven Rogers, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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