Anti-PID/MTA2 Antibody

Rabbit Polyclonal Antibody specific to PID/MTA2

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Metastasis-associated 1-like 1, MTA1-L1 protein, p53 target protein in deacetylase complex

Gene Name

MTA2

NCBI Gene ID

UniProt

O94776

Cellular Locus

Nucleus

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide corresponding to aa 652-668 of human PID/MTA2. This sequence differs from that of mouse by one amino acid.

Target Antigen

Metastasis-associated protein MTA2

Target

PID/MTA2

Clonality

Polyclonal

Type

Antibody

Applications

ELISA, WB, ICC, IF, IHC-P

Field of Research

Cancer research

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Additionnal Information

Immunoblotting: use at 0.5-1 ug/mL. In immunoblots, a band of 75 kD is detected. <br><br>Positive control: HeLa cell lysate.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes human, mouse, and rat PID/MTA2, a subunit of the nucleosome remodeling and deacetylating (NRD/NuRD) complex. PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex, and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53- dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis. PID/MTA2 is expressed in a variety of tissues. This antibody does not cross-react with MTA1.