GSK3787
GSK3787 is a selective and irreversible peroxisome proliferator-activated receptor δ (PPARδ) antagonist with pIC50 of 6.6.
Product Specifications
CAS Number
188591-46-0
UNSPSC
12352005
Hazard Statement
H317, H319
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk3787.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(NCCS(=O)(C1=NC=C(C(F)(F)F)C=C1)=O)C2=CC=C(Cl)C=C2
Molecular Formula
C15H12ClF3N2O3S
Molecular Weight
392.78
Precautions
H317, H319
References & Citations
[1]Shearer BG, et al. Identification and characterization of 4-chloro-N- (2-{[5-trifluoromethyl) -2-pyridyl]sulfonyl}ethyl) benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist. J Med Chem. 2010 Feb 25;53 (4) :1857-61.|[2]Palkar PS, et al. Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787. Mol Pharmacol. 2010 Sep;78 (3) :419-30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARβ/δ
Available Sizes
Frequently Asked Questions
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