Hesperetin-d3
Product Specifications
UNSPSC Description
Hesperetin-d3 is the deuterium labeled Hesperetin[1]. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis[2][3].
Target Antigen
Apoptosis; Autophagy; p38 MAPK
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis;Autophagy;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C1C[C@@H](C2=CC=C(OC([2H])([2H])[2H])C(O)=C2)OC3=CC(O)=CC(O)=C13
Molecular Weight
305.30
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39(12):2052-2059.|[3]Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Curated Selection
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