(-) -Indolactam V

(-) -Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

Product Specifications

CAS Number

[90365-57-4]

Product Name Alternative

Indolactam V

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

PKC

Type

Reference compound

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/_-_-Indolactam-V.html

Purity

98.75

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)[C@@H](C1=O)N(C)C2=C3C(NC=C3C[C@H](N1)CO)=CC=C2

Molecular Formula

C17H23N3O2

Molecular Weight

301.38

Precautions

H315, H319, H335

References & Citations

[1]Nakagawa Y, et al. Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-) -indolactam-V. Biosci Biotechnol Biochem. 1997 Aug;61 (8) :1415-7.|[2]Masuda A, et al. Binding selectivity of conformationally restricted analogues of (-) -indolactam-V to the C1 domains of protein kinase C isozymes. Biosci Biotechnol Biochem. 2002 Jul;66 (7) :1615-7.|[3]Chen S, et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr;5 (4) :258-65.