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P-Coumaric Acid Ethyl Ester

P-Coumaric Acid Ethyl Ester (Ethyl (E) -p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate) is a non-competitive, reversible inhibitor of tyrosinase (IC50=4.89 μg/mL, Ki=1.83 μg/mL), which can quench the intrinsic fluorescence of the enzyme. p-Coumaric Acid Ethyl Ester changes the binding affinity of L-tyrosine by inducing conformational changes in the catalytic domain of tyrosinase, and does not bind to the copper ion of the enzyme. p-Coumaric Acid Ethyl Ester is used in the development of medicines, cosmetics and fruit preservation products using pollen[1].

Product Specifications

CAS Number

7362-39-2

Product Name Alternative

Ethyl (E) -p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Tyrosinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/p-coumaric-acid-ethyl-ester.html

Purity

99.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCOC(/C=C/C1=CC=C(O)C=C1)=O

Molecular Formula

C11H12O3

Molecular Weight

192.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Li L, et al. Tyrosinase inhibition by p-coumaric acid ethyl ester identified from camellia pollen. Food Sci Nutr. 2020 Dec 11;9 (1) :389-400.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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