P-Coumaric Acid Ethyl Ester
P-Coumaric Acid Ethyl Ester (Ethyl (E) -p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate) is a non-competitive, reversible inhibitor of tyrosinase (IC50=4.89 μg/mL, Ki=1.83 μg/mL), which can quench the intrinsic fluorescence of the enzyme. p-Coumaric Acid Ethyl Ester changes the binding affinity of L-tyrosine by inducing conformational changes in the catalytic domain of tyrosinase, and does not bind to the copper ion of the enzyme. p-Coumaric Acid Ethyl Ester is used in the development of medicines, cosmetics and fruit preservation products using pollen[1].
Product Specifications
CAS Number
[7362-39-2]
Product Name Alternative
Ethyl (E) -p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Tyrosinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/p-coumaric-acid-ethyl-ester.html
Purity
99.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCOC(/C=C/C1=CC=C(O)C=C1)=O
Molecular Formula
C11H12O3
Molecular Weight
192.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Li L, et al. Tyrosinase inhibition by p-coumaric acid ethyl ester identified from camellia pollen. Food Sci Nutr. 2020 Dec 11;9 (1) :389-400.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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