VU0405601
VU0405601 is a potent KV11.1 channel activator. VU0405601 protects cardiac tissue from Dofetilide -induced ventricular tachycardia[1][2].
Product Specifications
CAS Number
712325-30-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vu0405601.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(COC1=CC=C2C=CC=CC2=C1Br)NC3=CC=CN=C3
Molecular Formula
C17H13BrN2O2
Molecular Weight
357.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Egly CL, et al. A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient KV11.1 (hERG) Variants. Mol Pharmacol. 2022 Apr;101 (4) :236-245. |[2]Potet F, et al. Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG) -related drug-induced arrhythmias. J Biol Chem. 2012 Nov 16;287 (47) :39613-25.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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