VU0405601

VU0405601 is a potent KV11.1 channel activator. VU0405601 protects cardiac tissue from Dofetilide (HY-B0232) -induced ventricular tachycardia[1][2].

Product Specifications

CAS Number

[712325-30-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/vu0405601.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(COC1=CC=C2C=CC=CC2=C1Br)NC3=CC=CN=C3

Molecular Formula

C17H13BrN2O2

Molecular Weight

357.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Egly CL, et al. A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient KV11.1 (hERG) Variants. Mol Pharmacol. 2022 Apr;101 (4) :236-245. |[2]Potet F, et al. Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG) -related drug-induced arrhythmias. J Biol Chem. 2012 Nov 16;287 (47) :39613-25.