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D-Glucan

D-Glucan is an orally effective Dectin-1 receptor immune activator with antioxidant properties (reducing TNF-α). D-Glucan activates macrophages and neutrophils to scavenge free radicals, inhibit oxidative stress and inflammatory responses, and improve insulin sensitivity. D-Glucan promotes glycolysis by enhancing the activity of the antioxidant enzyme glutathione, inhibiting gluconeogenesis and activating GK. D-Glucan can be used in the research of liver damage protection (antagonizing Acetaminophen toxicity), radiation protection (synergistic with vitamin E) and diabetes (improving glucose metabolism)[2][3][4].

Product Specifications

CAS Number

9012-72-0

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Toll-like Receptor (TLR)

Type

Biochemical Assay Reagents

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/d-glucan.html

Purity

96.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[D-Glucan]

Precautions

H302, H315, H319, H335

References & Citations

[1]Ljungman AG, et al. (1→3) -β-d-Glucan stimulates nitric oxide generation and cytokine mRNA expression in macrophages. Environ Toxicol Pharmacol. 1998 Jun 2;5 (4) :273-81.|[2]Toklu HZ, et al. Acetaminophen-induced toxicity is prevented by beta-D-glucan treatment in mice. Eur J Pharmacol. 2006 Aug 14;543 (1-3) :133-40.|[3]Tabeie F, et al. Radioprotective Effect of Beta D-Glucan and Vitamin E on Gamma Irradiated Mouse. J Clin Diagn Res. 2017 Feb;11 (2) :TC08-TC11.|[4]Liu M, et al. The anti-diabetic activity of oat β-d-glucan in streptozotocin-nicotinamide induced diabetic mice. Int J Biol Macromol. 2016 Oct;91:1170-6.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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