MCG-02
MCG-02 is the inhibitor for cruzain (CRZ) and cathepsin L-like protease (CATL), that inhibits the CRZ in Trypanosoma cruzi and CATL in Trypanosoma brucei with the IC50 0.2 μM and 0.02 μM[1].
Product Specifications
UNSPSC
12352211
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mcg-02.html
Smiles
CC1=CC=C2C(OC(C(/C(C)=N/NC(N)=S)=C2)=O)=C1
Molecular Formula
C13H13N3O2S
Molecular Weight
275.33
References & Citations
[1]Nunes JA, et al., Nanomolar activity of coumarin-3-thiosemicarbazones targeting Trypanosoma cruzi cruzain and the T. brucei cathepsin L-like protease. Eur J Med Chem. 2024 Nov 28;283:117109.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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