Ferulic acid
Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.
Product Specifications
CAS Number
1135-24-6
Product Name Alternative
Coniferic acid
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Endogenous Metabolite; FGFR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ferulic_acid.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C/C1=CC=C(O)C(OC)=C1
Molecular Formula
C10H10O4
Molecular Weight
194.19
Precautions
H315, H319, H335
References & Citations
[1]Yang GW, et al. Ferulic Acid Exerts Anti-Angiogenic and Anti-Tumor Activity by Targeting Fibroblast Growth Factor Receptor 1-Mediated Angiogenesis. Int J Mol Sci. 2015 Oct 12;16 (10) :24011-31.|[2]Zeni AL, et al. Ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: evidence for the involvement of the serotonergic system. Eur J Pharmacol. 2012 Mar 15;679 (1-3) :68-74.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Citation 01
Appl Bionics Biomech. 2022 Jul 31:2022:6148361.|Arab J Chem. 2024 Aug.|Biol Proced Online. 2025 Jun 16;27 (1) :21.|CNS Neurosci Ther. 2023 Jun;29 Suppl 1 (Suppl 1) :161-184.|Fish Shellfish Immunol. 2025 Aug 6:166:110633.|Food Chem. 2023 Mar 30;405 (Pt A) :134807.|Free Radic Biol Med. 2025 Aug 13:240:183-196.|Neurotherapeutics. 2023 Jul;20 (4) :1081-1108.|Pharmaceuticals (Basel) . 2022 Jan 31;15 (2) :179.|Phytomedicine. 2025 Jul:142:156713.|Phytomedicine. 2025 May:140:156573.|Research Square Preprint. 2024 Dec 17.
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