Ferulic acid

Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

Product Specifications

CAS Number

[1135-24-6]

Product Name Alternative

Coniferic acid

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; FGFR

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Ferulic_acid.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C/C1=CC=C(O)C(OC)=C1

Molecular Formula

C10H10O4

Molecular Weight

194.19

Precautions

H315, H319, H335

References & Citations

[1]Yang GW, et al. Ferulic Acid Exerts Anti-Angiogenic and Anti-Tumor Activity by Targeting Fibroblast Growth Factor Receptor 1-Mediated Angiogenesis. Int J Mol Sci. 2015 Oct 12;16 (10) :24011-31.|[2]Zeni AL, et al. Ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: evidence for the involvement of the serotonergic system. Eur J Pharmacol. 2012 Mar 15;679 (1-3) :68-74.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

Launched

Citation 01

Appl Bionics Biomech. 2022 Jul 31:2022:6148361.|Arab J Chem. 2024 Aug.|Biol Proced Online. 2025 Jun 16;27 (1) :21.|CNS Neurosci Ther. 2023 Jun;29 Suppl 1 (Suppl 1) :161-184.|Fish Shellfish Immunol. 2025 Aug 6:166:110633.|Food Chem. 2023 Mar 30;405 (Pt A) :134807.|Free Radic Biol Med. 2025 Aug 13:240:183-196.|Neurotherapeutics. 2023 Jul;20 (4) :1081-1108.|Pharmaceuticals (Basel) . 2022 Jan 31;15 (2) :179.|Phytomedicine. 2025 Jul:142:156713.|Phytomedicine. 2025 May:140:156573.|Research Square Preprint. 2024 Dec 17.