BIX02188

BIX02188 is a potent MEK5-selective inhibitor with an IC50 of 4.3 nM. BIX02188 inhibits ERK5 catalytic activity, with an IC50 of 810 nM.

Product Specifications

CAS Number

[334949-59-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ERK; MEK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BIX02188.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : ≥ 45 mg/mL

Smiles

O=C(N)C1=CC(NC2=O)=C(/C2=C(C3=CC=CC=C3)/NC4=CC=CC(CN(C)C)=C4)C=C1

Molecular Formula

C25H24N4O2

Molecular Weight

412.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Li L, et al. Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun. 2008 May 23;370 (1) :159-63.|[2]Tatake RJ, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377 (1) :120-5.|[3]Badshah II, et al. Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. Front Pharmacol. 2014 Apr 21;5:71.